Evidence supporting the use of: Proanthocyanidin
For the health condition: Skin Care (general)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Proanthocyanidins, a class of polyphenolic compounds found in foods such as grapes, berries, and cocoa, have garnered scientific interest for their potential benefits in skin care. Several in vitro and animal studies, as well as a number of clinical trials, suggest that proanthocyanidins possess antioxidant, anti-inflammatory, and photoprotective properties. These mechanisms are thought to help protect the skin from oxidative stress, UV-induced damage, and premature aging. For example, grape seed proanthocyanidin extract (GSPE) has been shown in some clinical studies to improve skin elasticity, reduce hyperpigmentation, and enhance overall skin appearance, likely due to its capacity to scavenge free radicals and inhibit matrix metalloproteinases that degrade collagen.

Despite these promising findings, the evidence remains moderate. Most studies involve relatively small sample sizes, short durations, or are conducted in vitro or in animal models rather than large, rigorous human trials. However, the consistent antioxidant findings across studies provide a rational scientific basis for the use of proanthocyanidins in skin care products and dietary supplements aimed at general skin health. More large-scale randomized controlled trials are needed to confirm efficacy and determine optimal dosing. In summary, while traditional use exists, scientific evidence underpins the rationale for proanthocyanidins in supporting general skin care, with an evidence strength of 3 out of 5.

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Products containing Proanthocyanidin

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