Ursane-type triterpenoids, such as ursolic acid, have been studied for their roles in skin care due to their anti-inflammatory, antioxidant, and anti-aging properties. Scientific research demonstrates that ursolic acid can inhibit inflammatory mediators like COX-2 and reduce oxidative stress, both of which are implicated in skin aging and inflammatory skin conditions. Some in vitro and animal studies have shown that ursane-type triterpenoids enhance collagen production, promote wound healing, and may protect against UV-induced skin damage. For example, topical application of ursolic acid has been found to improve skin barrier function and reduce the depth of wrinkles in experimental models.

While these results are promising, most of the evidence comes from preclinical studies, including cell culture and animal models. Human clinical trials are limited, though some small-scale studies suggest beneficial effects in improving skin elasticity and reducing visible signs of aging. The mechanisms proposed include modulation of the extracellular matrix, inhibition of matrix metalloproteinases (MMPs), and scavenging of free radicals. As a result, ursolic acid and related ursane-type triterpenoids are included in some cosmeceutical formulations targeting skin health and anti-aging benefits.

In summary, while there is a scientific rationale and preclinical evidence supporting the use of ursane-type triterpenoids for general skin care, robust clinical validation in humans is still emerging.