Tocofersolan, a water-soluble derivative of vitamin E (also known as TPGS or D-alpha-tocopheryl polyethylene glycol 1000 succinate), is used in dermatology primarily due to its antioxidant properties. Vitamin E is well-known for its role in protecting cell membranes from oxidative damage by neutralizing free radicals. In skin care, tocofersolan serves as a potent antioxidant, helping to reduce oxidative stress, which is implicated in skin aging and damage from environmental factors like UV radiation and pollution.

Several clinical and laboratory studies have investigated the topical and oral application of vitamin E and its derivatives for improving skin hydration, wound healing, and reducing the appearance of scars. While results are mixed, there is moderate evidence suggesting that vitamin E can support skin barrier function and help in conditions associated with oxidative stress. Tocofersolan’s improved solubility makes it especially valuable for use in water-based topical formulations and for patients with fat malabsorption syndromes.

However, not all studies show significant clinical benefits for every skin condition. The most robust evidence supports its use as an adjunct in protecting the skin from UV-induced damage and improving hydration. Overall, the scientific foundation for the use of vitamin E (including tocofersolan) in general skin care is moderate, with its antioxidant effect being the primary justification.