Vitamin E, including mixed tocotrienols, has scientific evidence supporting its role in general skin care. Vitamin E is a lipid-soluble antioxidant, and both tocopherols and tocotrienols are its naturally occurring forms, with tocotrienols exhibiting higher antioxidant potency in some studies. Research demonstrates that vitamin E can help protect skin from oxidative stress caused by environmental factors such as UV radiation and pollution. Topical application of vitamin E has been shown to reduce markers of oxidative damage, improve skin hydration, and support wound healing processes.

Clinical studies indicate that vitamin E may help reduce the severity of atopic dermatitis, protect against photodamage, and decrease skin inflammation. Tocotrienols, though less commonly studied than tocopherols, have been shown in some in vitro and animal studies to offer superior antioxidant protection and enhance skin barrier function. Human studies are more limited but suggest potential benefits for improving skin texture and resilience against environmental insults.

However, while the antioxidant benefits of vitamin E are well-established, robust clinical trials demonstrating dramatic or unique effects of tocotrienols (as opposed to tocopherols) for general skin health in humans are fewer. The evidence base is moderate, with further research needed to clarify the distinct advantages of tocotrienols. Overall, the use of vitamin E (including mixed tocotrienols) in skin care is scientifically supported, primarily for its antioxidant and photoprotective effects.