Silk protein, particularly in the form of hydrolyzed silk (such as sericin and fibroin), is used in skincare products aimed at improving skin hydration and texture. Scientific studies have demonstrated that silk proteins possess notable moisture-retaining properties, forming a protective barrier on the skin that helps to reduce transepidermal water loss. Laboratory and limited clinical studies indicate that sericin can enhance skin elasticity, promote hydration, and potentially soothe dry or flaky skin by mimicking the skin's natural moisturizing factors.

For instance, published research in peer-reviewed journals has shown that silk sericin can improve the moisture content of the stratum corneum (the outermost layer of the skin) and may support recovery in damaged or dry skin. Its biocompatibility and film-forming ability make it a favorable ingredient for topical formulations. However, the quality and quantity of human clinical data remain limited. Most available evidence comes from in vitro experiments, small-scale human trials, or animal studies, and larger, well-controlled clinical studies are lacking.

In summary, the use of silk protein for treating dry or flaky skin is supported by promising preliminary scientific evidence, particularly for its moisturizing and barrier-protective roles. However, more robust clinical trials are needed to confirm its efficacy and optimize its use in dermatological products.