Vitamin B2, also known as riboflavin, has scientific evidence supporting its role in maintaining healthy skin. Riboflavin is essential for cellular function, growth, and energy production, and it plays a critical role in the metabolism of fats, drugs, and steroids. Deficiency of riboflavin can lead to various skin-related symptoms, including dryness, scaling, and cracking of the skin, especially around the mouth (angular cheilitis) and nose. Clinical reports and case studies have documented that restoring riboflavin levels in deficient individuals leads to a resolution of these skin symptoms.

However, while riboflavin supplementation is effective in treating skin symptoms caused by its deficiency, there is limited evidence to support its use in individuals with normal riboflavin status for improving dry or flaky skin. Most research pertains to deficiency states rather than supplementation in the general population. Therefore, scientific validation exists primarily for the treatment of deficiency-related skin issues, rather than as a general remedy for dry or flaky skin unrelated to riboflavin status.

In summary, vitamin B2 is scientifically validated for supporting skin health in cases of deficiency, but its use as a treatment for dry or flaky skin in otherwise healthy individuals is not strongly supported by current evidence.