Evidence supporting the use of: 15,16-Dihydrotanshinone I
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

15,16-Dihydrotanshinone I is a bioactive compound isolated from Salvia miltiorrhiza (Danshen), a plant used in traditional Chinese medicine. While Danshen itself has been traditionally used for a variety of ailments, the specific use of 15,16-Dihydrotanshinone I for skin infections is supported primarily by in vitro and limited in vivo scientific studies rather than historical or extensive clinical evidence.

Several laboratory studies have demonstrated that 15,16-Dihydrotanshinone I exhibits notable antimicrobial activity against a range of pathogenic bacteria, including Staphylococcus aureus (including MRSA strains) and Propionibacterium acnes, both of which are relevant to skin infections. Mechanistically, this compound appears to disrupt bacterial cell membranes and inhibit biofilm formation, which is crucial in the context of chronic or resistant skin infections. Furthermore, 15,16-Dihydrotanshinone I has shown anti-inflammatory effects in cell-based assays, which may also be beneficial in treating skin infections that involve significant inflammatory responses.

However, the majority of these findings are preclinical, and there is a lack of substantial clinical data in humans. While the results are promising, the available evidence does not yet support routine or direct clinical use of 15,16-Dihydrotanshinone I for treating skin infections. Thus, the evidence is rated as 2 (limited preclinical scientific support), pending further research and clinical trials.

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