Evidence supporting the use of: Azelaic acid
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Azelaic acid is scientifically validated for use in certain skin conditions, notably acne and rosacea, due to its antimicrobial and anti-inflammatory properties. It inhibits the growth of Propionibacterium acnes and Staphylococcus epidermidis, bacteria implicated in acne pathogenesis, and reduces the formation of comedones and papules. Clinical trials have demonstrated that topical azelaic acid (typically at 15-20% concentration) is effective in reducing inflammatory and non-inflammatory acne lesions, with efficacy comparable to that of benzoyl peroxide, tretinoin, and topical antibiotics. Furthermore, azelaic acid is used in the treatment of mild to moderate rosacea, particularly for reducing papules and pustules.

While azelaic acid possesses antimicrobial activity, its use for primary skin infections (such as bacterial or fungal infections outside the context of acne or rosacea) is not standard practice. There is limited evidence supporting its use for non-acne skin infections in humans. Most scientific support pertains to its role in managing inflammatory skin conditions with a secondary infectious component. As such, azelaic acid is not a first-line therapy for skin infections in general but is validated for conditions where microbial involvement is part of the disease process, such as acne vulgaris and rosacea. The safety profile is favorable, with mild local irritation being the most commonly reported side effect.

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Products containing Azelaic acid

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