Babchi (Psidalea corylifolia, also known as Bakuchi or P. corylifolia) has a long-standing use in traditional Ayurvedic and Chinese medicine for various skin disorders, including vitiligo, psoriasis, eczema, and other skin infections. Its seeds and oil are most commonly used. The traditional rationale for its use is based on empirical observations and the doctrine of signatures, believing that the plant's properties could restore pigmentation and heal skin lesions. Its main active compound, psoralen, is known to have photosensitizing properties and is used in combination with ultraviolet light (PUVA therapy) for vitiligo and psoriasis in modern dermatology, but this is based on isolated compounds rather than crude babchi extracts.

Several preclinical (in vitro and animal) studies have demonstrated antimicrobial, antifungal, and anti-inflammatory effects of babchi extracts, which could support its traditional use for skin infections. However, robust human clinical trials on crude babchi preparations for skin infections are lacking. Case reports and small clinical studies exist for its role in vitiligo and psoriasis, but less so for general skin infections. Nonetheless, the historical use—supported by pharmacological studies showing antibacterial and antifungal activities—lends some credence to its use for skin infections.

In summary, the justification for using babchi for skin infections is primarily traditional, with moderate laboratory evidence but limited high-quality clinical validation. Safety concerns (notably phototoxicity and allergic reactions) also warrant caution.