Burning Bush (Euonymus atropurpureus), also known as Wahoo, has been traditionally used in various Native American and folk medicine systems, particularly for its purported skin-healing properties. Historical records indicate that preparations from the bark and roots were topically applied to treat skin infections, sores, and wounds. The rationale was often based on empirical observations rather than rigorous scientific study, and these uses were passed down through generations. Despite its traditional use, there is a lack of robust modern scientific studies specifically validating Burning Bush’s efficacy against skin infections. Some phytochemical analyses have identified compounds with potential antimicrobial or anti-inflammatory activity in related species, but direct clinical or laboratory evidence for Euonymus atropurpureus remains limited. The use of Burning Bush for skin conditions is therefore primarily supported by ethnobotanical accounts and traditional knowledge rather than scientific research. In summary, while Burning Bush has a history of traditional use for skin infections, there is insufficient scientific evidence to confirm its effectiveness or safety for this indication. Caution is advised, as some parts of the plant are toxic if ingested, and its medicinal use should not replace evidence-based medical treatments.