Fruit acids, also known as alpha hydroxy acids (AHAs) such as glycolic acid, lactic acid, citric acid, and malic acid, have been studied primarily for their exfoliating and skin-renewing properties. Their main dermatologic uses are for conditions like acne, photoaging, and hyperpigmentation. There is emerging but limited scientific evidence indicating that fruit acids may indirectly support the management of mild superficial skin infections. Their exfoliative action helps remove the outermost layer of dead skin cells, which can reduce microbial colonization and promote healthy skin turnover. Some in vitro studies have demonstrated that certain fruit acids possess mild antimicrobial properties, potentially inhibiting the growth of common skin pathogens, such as Staphylococcus aureus and Propionibacterium acnes. However, these effects are generally modest compared to standard topical antimicrobials.

Clinical guidelines do not currently recommend fruit acids as a primary or adjunctive treatment for skin infections. Their use is more established in cosmetic dermatology rather than infectious disease management. The evidence supporting their direct efficacy in treating active skin infections is limited (rated at 2/5), and further research is needed to clarify their potential role. In summary, while fruit acids may provide some supportive benefit by maintaining healthy skin barrier function and mild antimicrobial action, they are not a frontline therapy for skin infections.