Evidence supporting the use of: Glycyrrhetinic Acid
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Glycyrrhetinic acid, a bioactive compound derived from the hydrolysis of glycyrrhizin found in licorice root (Glycyrrhiza glabra), has documented use in dermatology, particularly for its anti-inflammatory, antimicrobial, and wound-healing properties. Scientific studies have shown that glycyrrhetinic acid exhibits antibacterial activity against common skin pathogens, including Staphylococcus aureus and Propionibacterium acnes, which are implicated in skin infections and acne. Its mechanism of action is thought to involve the disruption of bacterial cell membranes and inhibition of microbial growth. Additionally, glycyrrhetinic acid is known to modulate inflammatory pathways, notably by inhibiting enzymes like cyclooxygenase and reducing prostaglandin E2 formation, which helps in alleviating inflammation associated with skin infections.

Clinical evidence includes small-scale studies and topical formulations containing glycyrrhetinic acid that have shown efficacy in improving symptoms of atopic dermatitis, eczema, and seborrheic dermatitis, conditions often complicated by secondary infections. However, while these findings are promising, the body of evidence is not extensive; most studies are in vitro, animal models, or limited human trials. Despite this, glycyrrhetinic acid is commonly included in dermatological products in Europe and Asia for its supportive role in skin healing and infection control. In summary, the use of glycyrrhetinic acid for supporting skin infections is primarily based on scientific rationale and preliminary evidence, warranting further high-quality clinical trials for confirmation.

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