Evidence supporting the use of: Hydroxyquinoline
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Hydroxyquinoline, particularly 8-hydroxyquinoline and its derivatives, has a documented history of use for treating skin infections due to its antimicrobial properties. The compound acts as a chelating agent and exhibits broad-spectrum activity against bacteria and fungi, which underlies its inclusion in some topical antiseptic preparations. Historically, hydroxyquinoline derivatives such as clioquinol and oxine have been used in creams, ointments, and powders intended for superficial skin infections, fungal infections (such as athlete’s foot), and as adjuncts in wound care.

The scientific evidence primarily comes from in vitro studies and clinical experience rather than large-scale, contemporary randomized controlled trials. Hydroxyquinoline's mechanism involves disrupting microbial cell function by chelating essential metal ions, thereby inhibiting the growth of pathogens. Its use has declined with the advent of more targeted and less toxic antimicrobials, but it occasionally appears in combination topical agents.

Overall, the evidence base is moderate: there is clear antimicrobial activity and historical precedent for use in skin infections, but limited modern clinical trial data. Safety concerns, particularly regarding neurotoxicity with certain derivatives (notably clioquinol), have further restricted its use. Nevertheless, hydroxyquinoline remains an example of an older antimicrobial agent with both scientific basis and clinical utility in specific dermatological contexts.

More about Hydroxyquinoline
More about Skin (infections)

Other health conditions supported by Hydroxyquinoline

Athlete's Foot
Skin (infections)
Urinary Tract Infections

Products containing Hydroxyquinoline

We currently have no products on Vitabase that contain this ingredient.