Evidence supporting the use of: Immunoglobulin G
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Immunoglobulin G (IgG) is used in the management of certain serious skin infections and immune-mediated skin disorders, primarily on the basis of scientific evidence. Intravenous immunoglobulin (IVIG), which consists mostly of IgG, is employed as a therapy for various dermatological conditions, including but not limited to toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), pemphigus vulgaris, and some severe bacterial skin infections in immunocompromised patients.

The use of IVIG in these contexts is supported by clinical studies, case series, and expert consensus, though randomized controlled trials are limited due to the rarity and severity of some of these conditions. For example, in TEN and SJS, IVIG has been shown in several observational studies to reduce mortality and halt disease progression, likely by interfering with Fas-mediated keratinocyte apoptosis. In autoimmune blistering skin diseases such as pemphigus vulgaris and bullous pemphigoid, IVIG modulates immune responses and reduces pathogenic autoantibodies, providing benefit especially in refractory cases.

For direct treatment of infectious skin diseases, IVIG is less commonly first-line, but it can be considered in patients with immunodeficiencies (e.g., primary antibody deficiencies) who experience recurrent or severe skin infections. In these patients, IgG supplementation helps restore humoral immunity and prevent further infections.

Overall, the use of Immunoglobulin G in these dermatological contexts is scientifically validated, particularly in severe, refractory, or immune-mediated skin disease, though the highest level of evidence (randomized controlled trials) is sometimes lacking due to practical and ethical limitations.

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Products containing Immunoglobulin G

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