Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactoperoxidase is an enzyme naturally present in milk and various bodily secretions, and it has well-documented antimicrobial properties. Its use in supporting or treating skin infections is primarily justified by scientific evidence. Lactoperoxidase acts as part of the innate immune system by catalyzing the oxidation of thiocyanate ions in the presence of hydrogen peroxide, producing compounds with broad-spectrum antibacterial, antiviral, and antifungal effects. A number of in vitro studies demonstrate that lactoperoxidase-containing systems inhibit the growth of several pathogenic bacteria commonly implicated in skin infections, such as Staphylococcus aureus and Propionibacterium acnes. Furthermore, some topical formulations—including creams and gels—leverage lactoperoxidase (often in conjunction with other enzymes like glucose oxidase) to enhance skin barrier function, reduce microbial colonization, and support healing in minor wounds or acne. Clinical evidence, while promising, is less robust. Some small-scale clinical trials and observational studies report improvements in conditions like acne vulgaris and minor infected wounds when lactoperoxidase-containing products are used. However, large randomized controlled trials are lacking, and much of the available evidence is derived from laboratory or animal studies rather than extensive human trials. In summary, lactoperoxidase is scientifically substantiated as an antimicrobial agent for skin support, but the strength of direct clinical evidence for its efficacy in treating skin infections is moderate, warranting further research.

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Other ingredients used for Skin (infections)

Other health conditions supported by lactoperoxidase

Products containing lactoperoxidase

Metagenics Probioplex® Intensive Care Powder