Evidence supporting the use of: Mahonia (unspecified)
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Mahonia (commonly referring to Mahonia aquifolium, or Oregon grape) has a history of traditional use for skin conditions, but there is also scientific research supporting its effectiveness, particularly for inflammatory and infectious skin diseases. The root and bark of Mahonia contain isoquinoline alkaloids, such as berberine, which demonstrate antimicrobial, anti-inflammatory, and antiproliferative properties in laboratory studies.

Several clinical studies have focused on Mahonia aquifolium topical preparations (creams and ointments) for the treatment of psoriasis and atopic dermatitis. A few small clinical trials and case series have reported improvement in symptoms and clinical appearance in patients with these conditions, which are often complicated by secondary skin infections. The antimicrobial activity of berberine and related alkaloids against bacteria such as Staphylococcus aureus and Streptococcus species provides a plausible mechanism for Mahonia's use in skin infections. However, direct evidence from controlled human studies specifically targeting skin infections (rather than inflammatory dermatoses) remains limited.

In summary, Mahonia has a credible scientific rationale and some clinical data supporting its use as a topical agent for certain skin conditions, with antimicrobial effects that may benefit skin infections. However, the overall clinical evidence is moderate and further large-scale, high-quality studies are needed to fully establish efficacy and safety for infectious skin diseases.

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