Evidence supporting the use of: Monolaurin
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Monolaurin, a monoglyceride derived from lauric acid (found in coconut oil), has been investigated for its antimicrobial properties. Scientific studies, primarily in vitro (test tube or laboratory) and some animal models, demonstrate that monolaurin can disrupt the lipid membranes of certain bacteria, viruses, and fungi, including Staphylococcus aureus and Propionibacterium acnes, both of which are relevant to skin infections. Its mechanism involves solubilizing the microbial lipid bilayer, leading to cell lysis and death. These properties have made monolaurin a subject of interest for topical and oral use in the context of various skin infections and conditions like acne, folliculitis, and minor bacterial infections.

However, despite promising laboratory results, there is a lack of robust clinical evidence in humans. Few, if any, well-designed randomized controlled trials have evaluated the safety or efficacy of monolaurin for treating skin infections in real-world settings. Thus far, its use is primarily driven by extrapolation from laboratory data and some anecdotal or case-based reports. Regulatory agencies do not currently recognize monolaurin as a proven treatment for skin infections. In summary, while the scientific basis exists at a preclinical level, the evidence supporting its clinical efficacy remains limited, justifying a moderate evidence rating.

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