Oroxylum indicum, commonly known as the Indian trumpet tree, has a longstanding history of use in traditional medicine systems such as Ayurveda. In these traditions, various parts of the plant—particularly the bark and leaves—are applied topically or used in decoctions to treat a range of skin ailments, including infections, wounds, and ulcers. The rationale for its use is largely derived from empirical, longstanding practice, where it is believed to possess antimicrobial, anti-inflammatory, and wound-healing properties. While several in vitro and animal studies have demonstrated that extracts of Oroxylum indicum can inhibit the growth of certain bacteria and fungi, as well as reduce inflammation, robust clinical evidence in humans is lacking. The majority of scientific research remains preliminary, often limited to laboratory studies rather than controlled human trials. Therefore, the use of Oroxylum indicum for skin infections is primarily justified by tradition, with some modest preclinical evidence suggesting potential efficacy. However, until more rigorous clinical trials are conducted, its use for this purpose is best regarded as traditionally supported rather than scientifically validated.