Phellodendron bark, also known as Huang Bai in Traditional Chinese Medicine (TCM), has a long history of use for treating various skin conditions, especially those characterized by damp-heat and infections such as eczema, sores, abscesses, and ulcers. Its use is rooted primarily in traditional practices rather than scientific validation. Ancient texts like the "Shennong Bencao Jing" and subsequent TCM pharmacopeias describe Phellodendron bark as having "heat-clearing" and "dampness-drying" properties, making it a common remedy for skin inflammations and purulent skin disorders. Modern pharmacological studies have identified several bioactive compounds in Phellodendron bark, such as berberine, which exhibit broad-spectrum antimicrobial and anti-inflammatory effects in vitro. However, most of the available clinical evidence is anecdotal or derived from small, low-quality studies and animal models, rather than large, well-designed human clinical trials. These studies suggest potential for the bark’s extracts to inhibit the growth of certain bacteria and fungi relevant to skin infections. In summary, while there is historical and traditional support for the use of Phellodendron bark in treating skin infections, robust scientific validation is limited. The traditional use is well-documented in TCM, but further rigorous clinical research is needed to confirm its efficacy and safety for skin conditions in modern medical practice.