Premna, a genus in the Lamiaceae family, is widely used in traditional medicine systems, particularly in Ayurveda and various Southeast Asian folk medicines. Traditional texts and ethnobotanical surveys report the use of Premna species (such as Premna serratifolia) for the treatment of skin infections, wounds, and related dermatological ailments. Preparations typically involve the use of leaves or bark, applied topically as poultices or in decoctions. The rationale behind these uses is rooted in the belief that Premna possesses antimicrobial, anti-inflammatory, and wound-healing properties. Some limited in vitro studies have identified antimicrobial constituents, such as flavonoids and terpenoids, in Premna extracts, but the direct evidence supporting their effectiveness for skin infections in humans remains sparse. Thus, while Premna's use for skin infections is well-established in traditional medicine, scientific validation through controlled clinical trials is lacking. Most supporting data are from in vitro or animal studies, or are anecdotal/traditional reports. Therefore, the evidence level supporting its use for this condition is modest (rated 2 out of 5), reflecting a strong traditional basis but limited modern scientific substantiation.