Evidence supporting the use of: Serralysin
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Serralysin (also called serratiopeptidase) is a proteolytic enzyme produced by the bacterium Serratia marcescens. Its use in supporting or treating skin infections is primarily based on its anti-inflammatory and proteolytic properties. Scientific studies have shown that serralysin can break down protein-based debris in tissue and reduce inflammation, which may indirectly support the healing of skin infections, particularly when these are accompanied by swelling, pain, or excessive exudate. Some animal studies and small clinical trials have demonstrated benefits in reducing edema and promoting healing in various inflammatory conditions, including post-surgical swelling and traumatic injuries, but evidence specifically targeting skin infections is limited and mostly indirect.

There are no large, high-quality randomized controlled trials directly evaluating serralysin for the treatment of skin infections. However, its ability to disrupt biofilms and degrade extracellular proteins has sparked interest in its potential to enhance antibiotic efficacy or wound healing. In summary, while there is some scientific rationale and preliminary evidence supporting the adjunctive use of serralysin in skin conditions involving inflammation or infection, robust clinical evidence is lacking. Its use remains off-label and should not replace conventional antimicrobial therapy where infection is present.

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Products containing Serralysin

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