Evidence supporting the use of: Sesquiterpenic Acid
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Sesquiterpenic acids are a class of terpenoids commonly found in various medicinal plants, notably in some Artemisia and Inula species. Their use to support or treat skin infections is supported by some scientific evidence, though it remains preliminary and mostly derived from in vitro or animal studies. Specifically, sesquiterpenic acids such as helenalin (from Arnica montana) and other structurally related compounds have demonstrated antimicrobial and anti-inflammatory activities. Laboratory studies have shown that these compounds can inhibit the growth of certain bacteria and fungi associated with skin infections, including Staphylococcus aureus and Candida species. The anti-inflammatory effects may also contribute to the overall therapeutic potential for skin conditions.

However, robust clinical trials in humans are lacking, and the available studies are often limited to cell cultures or animal models. Traditional usage of plants containing sesquiterpenic acids does exist (for example, in the use of Arnica preparations for skin ailments), but the specific role of sesquiterpenic acids as isolated agents for skin infections is not well established in historical medical texts. Therefore, while some scientific evidence exists to support their potential use against skin infections, the evidence base is not strong, and more research is needed to confirm efficacy and safety in humans.

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