Evidence supporting the use of: Terpinen-4-ol
For the health condition: Skin (infections)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Terpinen-4-ol is a major active component of tea tree oil (Melaleuca alternifolia) and is well-studied for its antimicrobial properties, particularly in the context of skin infections. Multiple in vitro studies have demonstrated that terpinen-4-ol exhibits broad-spectrum antibacterial and antifungal activity, including efficacy against pathogens such as Staphylococcus aureus (including MRSA), Streptococcus pyogenes, and Candida species. These effects are attributed to its ability to disrupt microbial cell membranes and inhibit biofilm formation.

Clinical studies have further supported the topical use of tea tree oil formulations containing terpinen-4-ol for mild superficial skin infections, acne, and even some fungal infections like athlete’s foot (Tinea pedis). Randomized controlled trials have shown that tea tree oil gels and creams with standardized terpinen-4-ol content can reduce lesion counts and microbial load in conditions such as acne vulgaris and impetigo. Furthermore, terpinen-4-ol has demonstrated anti-inflammatory effects, potentially aiding in the reduction of redness and swelling associated with infections.

While most clinical trials have evaluated whole tea tree oil, terpinen-4-ol is recognized as the primary active component responsible for its antimicrobial action. The evidence base is robust for mild to moderate skin infections, though more studies are needed for severe or systemic infections. Overall, its topical use is scientifically validated, with efficacy comparable to some conventional treatments in certain skin conditions.

More about Terpinen-4-ol
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Products containing Terpinen-4-ol

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