Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Yellow root, most commonly referring to Hydrastis canadensis (goldenseal) or sometimes Xanthorhiza simplicissima, has a longstanding traditional use in North American herbal medicine, particularly among Native American tribes, for treating skin infections and wounds. The primary active constituent in yellow root is berberine, an alkaloid known for its bright yellow color and bitter taste. Historically, poultices, washes, or infusions made from the root were applied to skin lesions, ulcers, and minor wounds to promote healing and prevent infection. The use of yellow root for skin conditions was later adopted and popularized by early American settlers and herbalists.

While there is some preclinical evidence that berberine possesses antimicrobial properties against a range of bacteria and fungi, rigorous scientific studies specifically evaluating yellow root preparations for skin infections in humans are lacking. The evidence rating of 2 reflects the reliance on traditional knowledge and the limited direct scientific research. Most modern references to yellow root for skin infections continue to cite historical usage rather than clinical trials. Therefore, although the traditional use is well documented and supported by some laboratory findings, the lack of robust clinical data limits the strength of the recommendation for this use today.

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