Evidence supporting the use of: Aminobutyric acid (unspecified)
For the health condition: Sleep (restless and disturbed)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Aminobutyric acid, most commonly referring to gamma-aminobutyric acid (GABA), is a major inhibitory neurotransmitter in the human central nervous system and plays a key role in promoting relaxation and sleep. The rationale for using GABA supplements to support sleep, particularly in cases of restlessness or disturbed sleep, is derived from GABA’s physiological role in reducing neuronal excitability and promoting calmness. Some small clinical studies have reported that oral GABA supplementation can reduce the time it takes to fall asleep and improve sleep quality (e.g., Yamatsu et al., 2016; Abdou et al., 2006). However, the evidence is limited by small sample sizes, short study durations, and methodological concerns. Furthermore, there is ongoing debate about whether orally ingested GABA crosses the blood-brain barrier in sufficient quantities to exert significant central effects, which raises questions about the mechanism of action for dietary supplements.

Despite its physiological plausibility and some promising preliminary results, current scientific evidence supporting the effectiveness of aminobutyric acid supplementation for sleep disturbances is considered weak to moderate at best. Larger, well-controlled clinical trials are needed to establish its efficacy and clarify its mechanism. Therefore, while there is a scientific rationale and some early supporting data, robust scientific validation is lacking, and the overall evidence rating is low to moderate.

More about Aminobutyric acid (unspecified)
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Other health conditions supported by Aminobutyric acid (unspecified)

Anxiety
Epilepsy
Insomnia
Nervousness
Seizures
Sleep (restless and disturbed)
Stress
Tension

Products containing Aminobutyric acid (unspecified)

We currently have no products on Vitabase that contain this ingredient.