Evidence supporting the use of: Mandrake
For the health condition: Sleep (restless and disturbed)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Mandrake (Mandragora officinarum) has a long history of use in traditional herbal medicine, particularly in Europe and the Middle East, where it was believed to possess sedative and sleep-inducing properties. Folk traditions often attributed its effects to the presence of tropane alkaloids, such as scopolamine, hyoscyamine, and atropine, which are known to produce central nervous system depression at certain doses. Historically, mandrake roots were used in various formulations or even placed under pillows to ward off insomnia or promote restful sleep. Ancient texts, including references from Greek and Roman sources, suggest its use as a sleep aid or even as an anesthetic in surgical procedures.

However, despite these traditional uses, there is limited modern scientific evidence to validate the efficacy or safety of mandrake for treating sleep disturbances. Most information regarding its effects comes from historical anecdotes rather than controlled clinical studies. Additionally, the presence of potent alkaloids makes the plant potentially toxic, with a narrow margin between therapeutic and harmful doses. Side effects can include hallucinations, dry mouth, confusion, and even fatal poisoning if misused.

In summary, mandrake’s use for sleep disturbances is rooted in tradition, but lacks robust scientific validation and poses significant safety concerns. Its use today is rare and discouraged outside of historical or folkloric contexts.

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Products containing mandrake

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