Evidence supporting the use of: Pedicoccus acidilactici
For the health condition: Small Intestinal Bacterial Overgrowth

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Pediococcus acidilactici is a lactic acid bacterium commonly used as a probiotic in food fermentation and animal health. There is a modest but emerging body of scientific evidence examining its potential role in gut health, including the management of Small Intestinal Bacterial Overgrowth (SIBO). Preclinical studies suggest P. acidilactici may help restore gut microbial balance, inhibit pathogenic bacteria, and modulate immune responses, all of which could be beneficial in SIBO. For example, some animal studies have shown that P. acidilactici can suppress the growth of harmful bacteria and support epithelial barrier function. Human studies, however, are limited. A few small clinical trials and case reports with multispecies probiotics (occasionally including P. acidilactici) suggest possible benefits for gut symptoms, but these studies are not specific to SIBO and often include other probiotic strains, making it difficult to isolate the effects of P. acidilactici.

Overall, while there is some scientific rationale and preclinical support, direct clinical evidence in humans with SIBO is lacking. Therefore, its use for SIBO is based on extrapolation from broader probiotic research and mechanistic plausibility rather than robust clinical trials. More targeted research is needed to definitively establish its efficacy for this condition.

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