Evidence supporting the use of: Bacillus subtilis
For the body system: Small Intestines
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Bacillus subtilis is a spore-forming probiotic bacterium that has been investigated for its role in supporting the health of the small intestine. Scientific studies, including both animal and human trials, have shown that B. subtilis can positively modulate gut microbiota, enhance barrier function, and support immune responses in the intestinal tract. Its spores are resistant to stomach acid, allowing them to reach the small intestine intact, where they can germinate and exert their effects.
Several randomized controlled trials have demonstrated that supplementation with B. subtilis may help reduce symptoms of gastrointestinal discomfort, such as bloating and irregular bowel movements, particularly in individuals with mild digestive disturbances. Mechanistically, it appears to compete with pathogenic bacteria, produce antimicrobial compounds, and stimulate mucosal immunity, which can contribute to a healthier small intestinal environment.
However, the body of evidence in humans is still moderate, with more robust and long-term studies needed to fully establish its benefits for specific small intestine-related conditions. Regulatory authorities such as the European Food Safety Authority (EFSA) recognize B. subtilis as safe for use as a probiotic, but health claims are typically limited due to the variability in clinical outcomes. Overall, the use of Bacillus subtilis to support small intestinal health is grounded in scientific evidence, though it is not yet regarded as conclusive or universally applicable.
Other ingredients that support Small Intestines
2'-FucosyllactoseAcemannan
Agrimonia pilosa
Alchemilla
Alchornea
Algal protein
Aloe vera
alpha-galactosidase
Alpha-glycans
amino acids
aminopeptidase
amylase
animal protein
arabinoxylan
ashitaba
asparagus
Asteraceae
Bacillus
bacillus clausii
bacillus coagulans
Bacillus indicus
Bacillus licheniformis
bacillus subtilis
bacteria
bael
bayberry
bee products
berberine
Bifidobacteria
Bifidobacterium
Bifidobacterium adolescentis
Bifidobacterium animalis
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
bile
bile acid
bile salt
bitter principals
black seed
Boerhavia diffusa
bottle gourd
bran
Brassica
broccoli
Brussel sprouts
Buckwheat
butternut
butyrate triglyceride
butyric acid
cape aloe
caprylic acid
carrot
carvacrol
cayenne pepper
Centella triterpenes
chia seed
chickpea protein
chicory
Chitin-Glucan Complex
Cinnamomum
cinnamon
Citrus
Clostridium butyricum
colostrum
corktree
cowpea
cruciferous
curry leaf
Debaryomyces hansenii
diamine oxidase
dioscorea
egg
Egg protein
electrolytes blend (proprietary)
endo-peptidase
Enterococcus
enzyme blend
enzymes blend (proprietary)
Eucheuma
exo-peptidase
fatty acids
fennel
fenugreek
fiber
fiber blend (proprietary)
fig
fish
flavones
flavonoids
flavonols
flaxseed
folate
Foxtail millet
fringetree
fructooligosaccharides (FOS)
fruit
fungal enzymes blend (proprietary)
fungal protease
galactooligosaccharides
galactosidase
ginger
Glucooligosaccharides
glucose
Glutamine
Glutenase
Glycomacropeptides
Glycyrrhizin
goldthread
green banana
green tea
Gymnema
Gymnema sylvestre
herbal blend (proprietary)
honey
immunoglobin G
Immunoglobulin G
intrinsic factor
inulin
isomalto-oligosaccharide
kale
Kefir
kiwi
Kluyveromyces lactis
Kluyveromyces marxianus
Konjac
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
L-glutamine
L. lactis
lactalbumin
lactase
lactiplantibacillus plantarum
Lactobacillus
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus helveticus
Lactobacillus johnsonii
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactobacillus paracasei
Lactobacillus pentosus
Lactobacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus sakei
Lactobacillus salivarius
Lactococcus casei
Lactococcus lactis
Lactococcus rhamnosus
Lactoferrin
Legume protein
lemon
Lentil
lingzhi
lipase
lipids
magnesium
maltase
mannans
Marshmallow
Matapalo Tree
medium chain triglycerides (MCT)
Microbial enzymes (proprietary)
Milk Protein
Millet
millet seed
Mimosa
Mineral ascorbate
Monounsaturated fat
Mucilage
Mung bean
Mushroom
N-acetyl-glucosamine
Nigella seed
okra
Oligosaccharides
ox bile
Paenibacillus polymyxa
pancreatin
papaya
parsley
pear
Pediococcus acidilactici
Pediococcus pentosaceus
Peptidase
peptidase (DPPIV)
Peptides
phaseolamin
phellodendron amurense
phenolic compounds
phospholipids
Phyllanthus
phytase
Piperine
polyphenols
polysaccharides
Portulaca
prebiotic blend (proprietary)
probiotics
prolyl endopeptidase (PEP)
Propionibacterium freudenreichii
protease
protein
proteolytic enzymes
Pterocarpus marsupium
pu-er tea
pumpkin
purslane
rice
rockweed
Saccharomyces boulardii
Salacia
Salmon Oil
Sargassum
Scimitar bean
seaweed
Slippery Elm
slippery elm bark
Soy Protein
soybean
Spelt
spinach
streptococcus thermophilus
sucrase
sulforaphane glucosinolate
Tagatose
Taka amylase
Terpenoids
Tiger Nut
trace minerals
tributyrin
turmeric
vitamin A
vitamin B
vitamin D
vitamin D3
Watermelon
xylooligosaccharides
Yacon
Yarrow
Zinc
Other body systems supported by bacillus subtilis
Digestive SystemGastrointestinal Tract
Immune System
Intestinal System
Large Intestines (Colon)
Peyer’s patches
Small Intestines
Stomach
