Fungal enzymes, commonly derived from species such as Aspergillus oryzae, Aspergillus niger, and Rhizopus, are frequently included in dietary supplements to aid digestive function, particularly in the small intestine. These enzyme blends typically include amylases, proteases, lipases, and other enzymes capable of breaking down carbohydrates, proteins, and fats. There is a moderate body of scientific evidence supporting the use of supplemental fungal enzymes for enhancing digestive processes, especially in individuals with enzyme insufficiencies or certain digestive disorders. Published studies have shown that supplemental enzymes can improve digestion and nutrient absorption, reduce symptoms such as bloating and gas, and assist in the breakdown of otherwise hard-to-digest food components.

However, most research focuses on enzyme supplementation in general, including animal and microbial sources, rather than specifically on proprietary fungal enzyme blends. The available clinical studies are often small, short-term, and may not directly address long-term outcomes or overall small intestine health in healthy individuals. Thus, while there is scientific rationale and some supportive evidence for the use of fungal enzyme blends to support digestive function—including in the small intestine—the strength of the evidence is moderate (rated 3/5), and more robust, large-scale clinical trials are needed for conclusive validation.