Evidence supporting the use of: Immunoglobulin G
For the body system: Small Intestines

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Immunoglobulin G (IgG) is a type of antibody that plays a critical role in immune defense, particularly in neutralizing pathogens and toxins. Orally-administered IgG, often derived from bovine serum or colostrum, is used in some dietary supplements aimed at supporting gut health, including the small intestine. Scientific studies, particularly those involving bovine immunoglobulins, suggest that supplemental IgG can bind to microbial antigens and toxins in the gut lumen, thereby preventing their attachment to the intestinal mucosa and supporting mucosal immunity. Some clinical evidence indicates that serum-derived bovine immunoglobulin (SBI) may help manage symptoms in patients with irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), likely through modulation of gut barrier function and immune responses. However, the evidence base is still emerging, and most studies are small or of moderate quality, leading to a moderate evidence rating of 3. There is growing support from randomized controlled trials and mechanistic studies, but more large-scale, high-quality research is needed to confirm long-term safety and efficacy. Thus, while there is a scientific rationale and preliminary evidence for the use of IgG to support small intestine health, particularly in the context of gut barrier integrity and immune modulation, claims should be tempered pending further research.

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Products containing Immunoglobulin G

We currently have no products on Vitabase that contain this ingredient.