Evidence supporting the use of: Polyphenols (mixed)
For the body system: Small Intestines
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Polyphenols, a broad class of naturally occurring compounds found in plants (such as flavonoids, phenolic acids, and lignans), have received growing scientific attention for their effects on the gastrointestinal tract, including the small intestine. Research indicates that polyphenols can influence gut health through several mechanisms: they exhibit antioxidant properties, modulate inflammatory responses, and interact with the gut microbiota. Multiple studies have demonstrated that polyphenols can help maintain the integrity of the intestinal barrier, reduce oxidative stress, and potentially protect against inflammation-induced damage in the small intestine. For example, certain polyphenols have been shown in animal and cell models to support tight junction proteins and reduce intestinal permeability ("leaky gut"). Additionally, polyphenols can selectively promote the growth of beneficial bacteria while inhibiting pathogens, indirectly supporting small intestinal health. However, most clinical evidence is preliminary, and much of the data are derived from in vitro or animal studies rather than large-scale human trials. While the mechanistic rationale is strong and the body of research is expanding, more robust human clinical trials are needed to confirm these benefits specifically for the small intestine. Overall, there is scientific basis for the use of polyphenols to support small intestinal health, but the evidence is moderate rather than conclusive at this time.
Other ingredients that support Small Intestines
2'-FucosyllactoseAloe vera
alpha-galactosidase
amino acids
amylase
amylopectin
asparagus
bacillus clausii
bacillus coagulans
bacillus subtilis
bayberry
berberine
Bifidobacterium bifidum
Bifidobacterium breve
Bifidobacterium infantis
Bifidobacterium lactis
Bifidobacterium longum
broccoli
rice
Brussel sprouts
butyrate triglyceride
caprylic acid
carrot
chia seed
chicory
cinnamon
coating
colostrum
turmeric
endo-peptidase
exo-peptidase
fennel
fenugreek
fiber blend (proprietary)
flavonols
flaxseed
folate
fructooligosaccharides (FOS)
fungal protease
ginger
green banana
green tea
Gymnema sylvestre
cellulose
immunoglobin G
inulin
isomalto-oligosaccharide
kale
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
L-alanyl-L-glutamine
L-glutamine
lactase
Lactobacillus acidophilus
Lactobacillus brevis
Lactobacillus bulgaricus
Lactobacillus casei
Lactobacillus fermentum
Lactobacillus gasseri
Lactobacillus helveticus
Lactobacillus paracasei
lactiplantibacillus plantarum
Lactobacillus reuteri
Lactobacillus rhamnosus
Lactobacillus salivarius
Lactococcus lactis
Lactoferrin
lemon
lipase
magnesium
Marshmallow
medium chain triglycerides (MCT)
Microbial enzymes (proprietary)
N-acetyl-glucosamine
okra
ox bile
pancreatin
parsley
pear
peptidase (DPPIV)
phellodendron amurense
phenolic compounds
phospholipids
phytase
potato starch
prebiotic blend (proprietary)
prolyl endopeptidase (PEP)
protease
protein
butyric acid
pumpkin
Saccharomyces boulardii
slippery elm bark
soybean
spinach
streptococcus thermophilus
sucrase
sulforaphane glucosinolate
tributyrin
vitamin A
vitamin B
vitamin D
vitamin D3
seaweed
Water
Watermelon
xylooligosaccharides
Zinc
papaya
Pterocarpus marsupium
lingzhi
Yarrow
bile salt
sodium salt
dioscorea
electrolytes blend (proprietary)
polyphenols
trace minerals
purslane
fungal enzymes blend (proprietary)
millet seed
herbal blend (proprietary)
chickpea protein
enzymes blend (proprietary)
cayenne pepper
ashitaba
aminopeptidase
Alchornea
Alpha-glycans
Alchemilla
Agrimonia pilosa
Asteraceae
Acemannan
Algal protein
arabinoxylan
animal protein
black seed
Bifidobacterium
Bacillus indicus
Bifidobacterium adolescentis
Brassica
bran
bael
butternut
Bacillus licheniformis
bile
Bifidobacterium animalis
bee products
bitter principals
bacteria
Bifidobacteria
bile acid
Bacillus
Buckwheat
Boerhavia diffusa
bottle gourd
Centella triterpenes
curry leaf
cowpea
Cinnamomum
carvacrol
cape aloe
Citrus
cruciferous
Chitin-Glucan Complex
corktree
Clostridium butyricum
Debaryomyces hansenii
diamine oxidase
Enterococcus
egg
Eucheuma
enzyme blend
Egg protein
fig
fruit
fiber
flavonoids
fish
fatty acids
fringetree
Foxtail millet
flavones
goldthread
Glycomacropeptides
Glutamine
Glucooligosaccharides
galactosidase
Glutenase
glucose
galactooligosaccharides
Gymnema
Glycyrrhizin
honey
Immunoglobulin G
intrinsic factor
Konjac
Kluyveromyces lactis
kiwi
Kefir
Kluyveromyces marxianus
Lactobacillus plantarum
Lactobacillus pentosus
Lactobacillus sakei
Lactobacillus kefiranofaciens
Lactobacillus kefiri
Lactococcus rhamnosus
Legume protein
Lentil
Lactococcus casei
Lactobacillus johnsonii
lactalbumin
Lactobacillus
L. lactis
lipids
maltase
Mineral ascorbate
Mung bean
Mucilage
Millet
mannans
Monounsaturated fat
Milk Protein
Matapalo Tree
Mimosa
Mushroom
Nigella seed
Oligosaccharides
Piperine
Phyllanthus
Peptidase
polysaccharides
Pediococcus pentosaceus
Paenibacillus polymyxa
proteolytic enzymes
Propionibacterium freudenreichii
probiotics
Pediococcus acidilactici
pu-er tea
Portulaca
phaseolamin
Peptides
rockweed
Scimitar bean
Salmon Oil
Slippery Elm
Spelt
Salacia
Soy Protein
Sargassum
Terpenoids
Tagatose
Tiger Nut
Taka amylase
Yacon
Other body systems supported by Polyphenols (mixed)
ArteriesBlood
Brain
Capillaries
Circulatory System
Digestive System
Eyes
Gastrointestinal Tract
Gums
Heart
Hepatic System
Immune System
Intestinal System
Joints
Large Intestines (Colon)
Liver
Lungs
Mitochondria
Nerves
Prostate
Respiratory System
Skeletal System (Bones)
Skin
Small Intestines
Stomach