Evidence supporting the use of: Vitamin B9 (calcium methyltetrahydrofolate)
For the body system: Small Intestines
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Vitamin B9, also known as folate or folic acid, and in the form of calcium methyltetrahydrofolate, is scientifically validated as essential for various metabolic processes, particularly in tissues with rapid cell turnover like the small intestine. The small intestine’s lining is replaced every few days, requiring active cell division and DNA synthesis, both of which depend on adequate folate availability. Deficiency in folate can lead to impaired DNA synthesis and repair, resulting in reduced regenerative capacity of the intestinal mucosa, malabsorption, and even gastrointestinal symptoms such as diarrhea.
Human and animal studies have demonstrated that folate deficiency impairs the integrity and function of the intestinal epithelium. For example, research published in Gut and The American Journal of Clinical Nutrition has shown that folate-deficient diets lead to villous atrophy and mucosal abnormalities in the small intestine. Supplementation with bioavailable forms of folate, such as calcium methyltetrahydrofolate, restores normal mucosal architecture and supports healthy intestinal function. The form calcium methyltetrahydrofolate is especially relevant for individuals with genetic polymorphisms affecting folate metabolism (e.g., MTHFR mutations), ensuring effective absorption and utilization.
While folate is not specifically used to treat small intestine diseases directly, its role in supporting the rapid cell division and maintenance of the intestinal lining is well-established. Overall, scientific evidence supports the use of Vitamin B9 to maintain small intestinal health, particularly in preventing deficiencies that could compromise the mucosal lining.
More about Vitamin B9 (calcium methyltetrahydrofolate)
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Other body systems supported by Vitamin B9 (calcium methyltetrahydrofolate)
BloodBrain
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