Evidence supporting the use of: Vitamin D (cholecalciferol)
For the body system: Small Intestines

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitamin D (cholecalciferol) has scientific support for its role in small intestine function, primarily through its involvement in calcium and phosphate absorption. Vitamin D enhances the expression of calcium-binding proteins in the intestinal mucosa, particularly in the duodenum and jejunum, thereby facilitating efficient absorption of dietary calcium. This mechanism is well-documented in both animal and human studies. Deficiency of vitamin D leads to impaired calcium absorption, potentially resulting in conditions such as rickets in children and osteomalacia in adults, which are characterized by inadequate bone mineralization due to insufficient calcium uptake from the gut.

Additionally, vitamin D receptors (VDR) are present throughout the gastrointestinal tract, indicating a direct effect of vitamin D on intestinal health. Some research also suggests vitamin D may play a role in maintaining the integrity of the intestinal barrier and modulating immune responses in the gut. However, while vitamin D is crucial for nutrient absorption, its direct use as a therapy for small intestine-specific diseases (such as Crohn’s disease or celiac disease) is less established, and its benefits in these contexts are still being explored.

In summary, vitamin D’s support of the small intestine is scientifically validated and centers on its essential role in mineral absorption and, potentially, mucosal health. The evidence is robust for nutrient absorption, but more limited regarding direct effects on small intestine pathologies, resulting in a moderate evidence rating.

More about Vitamin D (cholecalciferol)
More about Small Intestines

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Products containing Vitamin D (cholecalciferol)

We currently have no products on Vitabase that contain this ingredient.