Relationship: Small Intestines and vitamin D3

Evidence supporting the use of: Vitamin D3
For the body system: Small Intestines

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) is primarily known for its role in calcium homeostasis and bone health. However, there is some scientific evidence that vitamin D3 also impacts the small intestine, particularly in the regulation of calcium and phosphate absorption. The small intestine is the primary site where dietary calcium is absorbed, a process that is significantly enhanced by active vitamin D3 (calcitriol). This mechanism is well-documented and underpins the rationale for vitamin D3 supplementation in conditions like osteoporosis and rickets, where improved calcium absorption is desired.

Beyond mineral absorption, limited evidence suggests that vitamin D3 may influence the integrity of the intestinal barrier and modulate local immune responses. Some preclinical studies and small human trials indicate that vitamin D receptors are present in the intestinal epithelium, and deficiency has been associated with an increased risk of inflammatory bowel diseases (IBD) such as Crohn’s disease. However, direct benefits of vitamin D3 supplementation specifically for general small intestine health, outside of calcium absorption and certain disease conditions, are not well-established.

In summary, while there is scientific validation for the role of vitamin D3 in supporting the small intestine’s function in mineral absorption, evidence for broader benefits on small intestine health or function is limited. Therefore, the level of evidence is rated as 2 out of 5.

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Other ingredients that support Small Intestines

2'-Fucosyllactose
aloe vera
alpha-galactosidase
amino acids
amylase
amylopectin
asparagus
bacillus clausii
bacillus coagulans
bacillus subtilis
bayberry
berberine
bifidobacterium bifidum
bifidobacterium breve
bifidobacterium infantis
bifidobacterium lactis
bifidobacterium longum
broccoli
rice
brussel sprouts
butyrate triglyceride
caprylic acid
carrot
chia seed
chicory
cinnamon
coating
colostrum
turmeric
endo-peptidase
exo-peptidase
fennel
fenugreek
fiber blend (proprietary)
flavonols
flaxseed
folate
fructooligosaccharides (FOS)
fungal protease
ginger
green banana
green tea
gurmar
cellulose
immunoglobin G
inulin
isomalto-oligosaccharide
kale
l-5-methyltetrahydrofolate glucosamine salt (5-MTHF)
l-alanyl-l-glutamine
l-glutamine
lactase
lactobacillus acidophilus
lactobacillus brevis
lactobacillus bulgaricus
lactobacillus casei
lactobacillus fermentum
lactobacillus gasseri
lactobacillus helveticus
lactobacillus paracasei
lactiplantibacillus plantarum
lactobacillus reuteri
lactobacillus rhamnosus
lactobacillus salivarius
lactococcus lactis
lactoferrin
lemon
lipase
magnesium
marshmallow
medium chain triglycerides (MCT)
microbial enzymes (proprietary)
n-acetyl-glucosamine
okra
ox bile
pancreatin
parsley
pear
peptidase (DPPIV)
phellodendron amurense
phenolic acids
phospholipids
phytase
potato starch
prebiotic blend (proprietary)
prolyl endopeptidase (PEP)
protease
protein
butyric acid
pumpkin
saccharomyces boulardii
sardines
slippery elm bark
soybean
spinach
starch
streptococcus thermophilus
sucrase
sulforaphane glucosinolate
tributyrin
vitamin A
vitamin B
vitamin D
vitamin D3
seaweed
water
watermelon
xylooligosaccharides
zinc
papaya
pterocarpus marsupium
lingzhi
yarrow
bile salt
sodium salt
dioscorea
electrolytes blend (proprietary)
polyphenols
trace minerals
purslane
fungal enzymes blend (proprietary)
millet seed
herbal blend (proprietary)
chickpea protein
enzymes blend (proprietary)
cayenne pepper
ashitaba
Aminopeptidase
Alchornea
Alpha-glycans
Alchemilla
Agrimonia pilosa
Asteracea
Acemannan
Algal protein
Arabinoxylan
Animal protein
Black Seed
Bifidobacterium
Bacillus indicus
Bifidobacterium adolescentis
Brassica
Bran
Bael
Butternut
Bacillus licheniformis
Bile
Bifidobacterium animalis
Bee products
Bitter principals
Bacteria
Bifidobacteria
bile acid
Bacillus
Buckwheat
Boerhavia diffusa
Bottle gourd
Centella triterpenes
Curry leaf
Cowpea
Cinnamomum
Carvacrol
Cape Aloe
Citrus
Cruciferous
Chitin-Glucan Complex
Corktree
Clostridium butyricum
Debaryomyces hansenii
Diamine Oxidase
Enterococcus
Egg
Eucheuma
Enzyme Blend
Egg protein
Fig
Fiber
Flavonoids
Goldthread
Galactosidase
glucose
Milk Protein
Mimosa
Soy Protein

Other body systems supported by vitamin D3

Blood
Brain
Circulatory System
Glandular System
Heart
Immune System
Intestinal System
Kidneys
Lungs
Mitochondria
Muscles
Parathyroid Glands
Respiratory System
Skeletal System (Bones)
Skin
Small Intestines
Teeth

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Evidence supporting the use of: Vitamin D3
For the body system: Small Intestines

Table of Contents

Synopsis

Other ingredients that support Small Intestines

Other body systems supported by vitamin D3

Products containing vitamin D3

Health Concerns

Brands

Evidence supporting the use of: Vitamin D3For the body system: Small Intestines

Table of Contents

Synopsis

Other ingredients that support Small Intestines

Other body systems supported by vitamin D3

Products containing vitamin D3

Evidence supporting the use of: Vitamin D3
For the body system: Small Intestines