Zinc L-carnosine is a chelated compound combining zinc and the dipeptide L-carnosine, and there is scientific evidence supporting its use for small intestine and overall gastrointestinal mucosal health. Several clinical and preclinical studies have shown that zinc L-carnosine can help protect and repair the intestinal lining, particularly in conditions characterized by mucosal damage such as gastritis, ulcers, and certain drug-induced injuries. The compound has demonstrated the ability to promote mucosal healing, reduce inflammation, and enhance the integrity of the intestinal barrier. Its protective effects are thought to be due to a combination of zinc’s role in cellular repair and immune function, and L-carnosine’s antioxidant and membrane-stabilizing properties.

Research has specifically examined zinc L-carnosine’s benefits in cases of small intestinal injury, such as those caused by non-steroidal anti-inflammatory drugs (NSAIDs). For example, randomized controlled trials and animal studies have reported that supplementation can reduce intestinal permeability and histological damage. The bulk of clinical evidence comes from studies on gastric and duodenal ulcers, but mechanistic studies and emerging human data indicate potential benefits throughout the small intestine as well.

Overall, while most of the clinical research to date has focused on upper GI tract disorders, the mechanistic rationale and available evidence justify zinc L-carnosine’s supportive use for the small intestine, particularly for maintaining mucosal integrity and promoting healing after injury.