Evidence supporting the use of: Allyl isothiocyanate
For the health condition: Sore Throat

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Allyl isothiocyanate, the pungent compound found in mustard, horseradish, and wasabi, has a long history of traditional use for respiratory and throat ailments, including sore throat. Its use is primarily rooted in folk medicine practices, where spicy or pungent substances were believed to help “clear” the throat and airways, reduce discomfort, or have mild antimicrobial effects. Historically, mustard plasters and preparations containing mustard oil (rich in allyl isothiocyanate) were sometimes applied externally or used as gargles for throat symptoms.

However, direct scientific evidence supporting the efficacy of allyl isothiocyanate specifically for sore throat relief is limited. Some laboratory studies show that allyl isothiocyanate possesses antimicrobial properties against certain bacteria and fungi, suggesting a potential mechanism for reducing microbial load in the throat. Additionally, its irritant effect may transiently mask sore throat pain through counterirritation.

Despite these findings, clinical trials or robust scientific studies evaluating its effectiveness for sore throat in humans are lacking. Most contemporary uses of allyl isothiocyanate for sore throat are based on traditional or anecdotal evidence rather than rigorous research. Therefore, while some traditional practices persist, the scientific support for its use in treating sore throat remains weak.

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