Evidence supporting the use of: Dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
For the health condition: Sore Throat

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide is a primary alkamide found in Echinacea species, particularly Echinacea angustifolia and Echinacea purpurea. The traditional use of Echinacea for sore throat and other upper respiratory tract symptoms dates back to Native American practices and 19th-century North American herbal medicine. The plant was commonly prepared as teas, tinctures, or lozenges to alleviate throat irritation, inflammation, and infections.

Modern phytochemical studies have identified alkamides, including dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide, as major active constituents. These compounds have demonstrated immunomodulatory and mild anti-inflammatory effects in vitro and in animal models. However, clinical evidence specific to sore throat relief is limited and often not directly attributed to this isolated alkamide. Most clinical trials of Echinacea have focused on prevention or duration of the common cold rather than targeted treatment of sore throat, and results are mixed.

In summary, while the use of Echinacea—containing dodeca-2E,4E,8Z,10Z-tetraenoic acid isobutylamide—for sore throat is well established by tradition, high-quality, direct scientific validation for this specific indication and for the isolated alkamide is lacking. The evidence supporting its use for sore throat is mostly traditional, with some biological plausibility but insufficient clinical validation.

More about dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide
More about Sore Throat

Other health conditions supported by dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide

Circulation (poor)
Colds (general)
Colds (prevention)
Inflammation
Pain (general remedies for)
Sore Throat
Stress

Products containing dodeca-2E, 4E, 8Z, 10Z/tetraenoic acid isobutylamide

We currently have no products on Vitabase that contain this ingredient.