Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Fritillaria, particularly the bulbs of Fritillaria cirrhosa and related species, has a long history of use in Traditional Chinese Medicine (TCM) for relieving cough and treating sore throat. In TCM, fritillaria is known as "Chuan Bei Mu" and is valued for its purported ability to clear heat, moisten the lungs, and resolve phlegm. Historical texts and modern TCM practitioners often recommend fritillaria preparations, sometimes in combination with other herbs, for respiratory ailments involving throat irritation or inflammation. The traditional rationale is based on centuries of empirical use and is documented in classical herbal compendia. From a scientific perspective, there is limited but emerging evidence that fritillaria contains alkaloids (notably peimine and peiminine) which may have anti-inflammatory, antitussive (cough-suppressing), and expectorant effects. Some in vitro and animal studies have shown these compounds can reduce airway inflammation and suppress cough reflexes. However, robust clinical trials in humans specifically evaluating fritillaria for sore throat are lacking. Therefore, while traditional use is strong and some pharmacological mechanisms are plausible, the scientific evidence remains preliminary. In summary, fritillaria is primarily justified for sore throat treatment by traditional use, with some limited preclinical support but insufficient high-quality clinical research to strongly validate its efficacy for this indication.

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