Evidence supporting the use of: Licorice
For the health condition: Sore Throat

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Licorice (Glycyrrhiza glabra) has a long history of use in traditional medicine for soothing sore throats, but there is also a moderate body of scientific evidence supporting its effectiveness. Licorice contains compounds such as glycyrrhizin and flavonoids, which have demonstrated anti-inflammatory, demulcent (soothing), and antimicrobial properties. Several clinical studies have specifically examined the efficacy of licorice in managing sore throat symptoms, particularly in the context of postoperative throat pain following endotracheal intubation. For example, randomized controlled trials have shown that gargling with licorice solution before surgery can significantly reduce the severity and incidence of postoperative sore throat compared to placebo. The proposed mechanisms include licorice's ability to form a protective film over mucous membranes and reduce inflammatory responses in the throat.

However, while these results are promising, most studies focus on postoperative sore throat rather than sore throats from viral or bacterial infections. There is less robust evidence for its effectiveness in common sore throat cases seen in the general population. Nevertheless, the combination of traditional use and clinical research suggests that licorice may provide symptomatic relief for sore throat in some contexts. Caution is advised with long-term or excessive use due to potential side effects such as hypertension and hypokalemia associated with glycyrrhizin.

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