Evidence supporting the use of: Macamides
For the body system: Specific Hormones

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Macamides are unique fatty acid derivatives found in the root of Lepidium meyenii, commonly known as maca. Traditionally, maca has been used for centuries in the Andes to enhance fertility, energy, and sexual function, suggesting an ethnobotanical connection to hormone-related effects. However, direct human evidence specifically linking macamides to hormonal modulation is limited. Animal and in vitro studies have indicated that certain macamides might influence the endocannabinoid system, which could indirectly affect hormone balance, but robust clinical data are lacking. Most support for macamides as modulators of hormones is thus rooted in the traditional use of maca root for reproductive and endocrine health, rather than direct scientific validation of macamides themselves. No large-scale, high-quality human trials have established a causal relationship between macamides and specific hormonal endpoints, though historical and preliminary evidence keeps interest in this area alive. Until more rigorous studies are available, the use of macamides for hormone support remains primarily justified by traditional practices rather than strong scientific proof.

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