Evidence supporting the use of: Melatonin
For the body system: Specific Hormones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Melatonin is a hormone naturally produced by the pineal gland in the brain and is primarily known for its role in regulating the sleep-wake cycle. Its use in supporting the "Specific Hormones" body system is justified by scientific evidence, though the strength of the evidence varies depending on the hormonal context. Melatonin directly influences the endocrine system by signaling the timing of circadian rhythms and modulating the release of other hormones, such as luteinizing hormone and follicle-stimulating hormone, especially in relation to reproductive function.

Clinical studies have shown that melatonin supplementation can influence reproductive hormones and may play a role in the management of certain hormonal disorders. For example, melatonin has been investigated for its effects on the timing of puberty, menstrual cycle regulation, and its potential use in conditions such as polycystic ovary syndrome (PCOS) and menopause-related symptoms. Additionally, melatonin’s antioxidant properties may provide indirect hormonal support by protecting endocrine tissues from oxidative stress.

However, while there is moderate evidence for melatonin’s regulatory effects on certain hormones, its use as a general hormonal support supplement is not as well established as its role in sleep regulation. Most robust clinical evidence centers on its chronobiotic effects rather than direct modulation of a wide array of hormones. Therefore, while melatonin does interact with and influence some hormonal pathways, its evidence base for broad "Specific Hormone" support is moderate.

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