Evidence supporting the use of: Vitamin D
For the body system: Specific Hormones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Vitamin D plays a scientifically validated role in supporting the "Specific Hormones" body system, particularly with respect to calcium-regulating hormones such as parathyroid hormone (PTH) and its influence on sex hormones. Numerous studies demonstrate that vitamin D is crucial for calcium homeostasis, primarily by modulating the secretion of PTH. When vitamin D levels are low, PTH secretion increases to maintain serum calcium, which can have downstream effects on bone health and metabolism. Supplementation with vitamin D has been shown to suppress elevated PTH in individuals with deficiency, supporting the hormone balance involved in mineral metabolism.

In addition to its role with PTH, emerging evidence suggests that vitamin D status may influence reproductive hormones. For example, research in both men and women indicates correlations between adequate vitamin D levels and healthy testosterone and estrogen concentrations, though the evidence here is less robust and causality is not firmly established. Some interventional studies suggest improvements in sex hormone profiles with vitamin D supplementation, but more research is needed to clarify these effects.

Overall, the scientific evidence solidly supports vitamin D’s effect on the hormonal regulation of calcium and bone metabolism, with moderate but growing evidence for broader endocrine effects. This justifies its classification as a scientifically validated ingredient for supporting the Specific Hormones body system, with the strongest evidence surrounding its impact on PTH and calcium regulation.

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