Evidence supporting the use of: Vitex Agnus-Castus
For the body system: Specific Hormones

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Vitex agnus-castus, also known as chaste tree berry, is traditionally used to support the hormonal system, particularly in women. Scientifically, it has been studied primarily for its effects on the menstrual cycle and associated symptoms such as premenstrual syndrome (PMS) and mastalgia (breast pain). The active constituents are believed to act on the pituitary gland, modulating the secretion of prolactin and possibly influencing other reproductive hormones such as luteinizing hormone (LH).

Several randomized controlled trials and systematic reviews have found that Vitex agnus-castus extracts can significantly reduce symptoms of PMS and cyclic mastalgia, likely through lowering elevated prolactin levels. Notably, a 2012 Cochrane review concluded that there is high-quality evidence for its effectiveness in reducing PMS symptoms compared to placebo, though the effect sizes are moderate. The European Medicines Agency and the German Commission E have also acknowledged its use for menstrual disorders.

However, evidence supporting its use in other hormonal conditions, such as menopause or infertility, is less robust and generally insufficient. Adverse effects are rare and usually mild. In summary, while Vitex agnus-castus has a strong traditional background, its use for certain hormonal issues, particularly PMS and mastalgia, is also supported by moderate-quality scientific evidence.

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