Evidence supporting the use of: Acetyl-L-Carnitine
For the body system: Specific Neurotransmitters

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Acetyl-L-carnitine (ALCAR) is an acetylated form of the amino acid L-carnitine and is able to cross the blood-brain barrier. There is substantial scientific evidence that ALCAR can influence neurotransmitter systems, particularly acetylcholine and dopamine. Studies have shown that ALCAR increases acetylcholine synthesis and release, which is important for memory and cognitive function. In addition, ALCAR has been found to enhance dopamine signaling and may support neuronal energy metabolism and mitochondrial function.

Clinical trials and animal studies suggest that ALCAR supplementation may improve symptoms in neurodegenerative disorders such as Alzheimer's disease, mild cognitive impairment, and age-related cognitive decline, partly by modulating neurotransmitter activity. For example, a meta-analysis (Montgomery et al., 2003) showed that ALCAR had beneficial effects on cognitive performance in elderly patients. Moreover, ALCAR is being investigated for its potential in mood disorders, as it may impact serotonin and noradrenaline pathways as well.

While the evidence is strongest for its effects on cholinergic and dopaminergic systems, the precise mechanisms are still under investigation. Overall, the use of Acetyl-L-carnitine to support neurotransmitter function is supported by a robust body of preclinical and clinical research, justifying a relatively high evidence rating.

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