Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Adrafinil is a synthetic compound originally developed in France in the 1970s as a wakefulness-promoting agent. It is a prodrug for modafinil, meaning it is metabolized in the body to produce modafinil, which is the active compound. Modafinil and, by extension, adrafinil, are known to influence neurotransmitters such as dopamine, norepinephrine, and histamine, among others. These neurotransmitter systems are involved in arousal, alertness, and cognitive function.

The primary medical use of adrafinil (and modafinil) has been to treat narcolepsy and other sleep disorders characterized by excessive daytime sleepiness. Clinical studies on modafinil show that it increases extracellular dopamine by inhibiting dopamine reuptake and also impacts other neurotransmitter systems, supporting its use in promoting wakefulness and alertness. There is moderate scientific evidence from animal and human studies that adrafinil, via its conversion to modafinil, can enhance certain aspects of cognitive function and vigilance, particularly in sleep-deprived individuals.

However, direct studies on adrafinil are limited compared to those on modafinil. Most of the evidence supporting its influence on neurotransmitter systems comes from its pharmacological similarity to modafinil. While the mechanism is not entirely understood, the available evidence is sufficient to suggest that adrafinil does support the "Specific Neurotransmitters" body system, particularly those related to wakefulness and attention, but the evidence is not as robust or extensive as it is for modafinil itself.

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Other ingredients that support Specific Neurotransmitters

Other body systems supported by Adrafinil

Products containing Adrafinil