Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Alpha-lactalbumin is a whey protein found in mammalian milk, and it has gained attention for its potential effects on neurotransmitter systems, particularly serotonin. Scientific interest centers on alpha-lactalbumin's high content of tryptophan, an essential amino acid and precursor for serotonin synthesis in the brain. Several clinical studies have explored whether dietary supplementation with alpha-lactalbumin can influence cognitive performance, mood, and stress response by elevating plasma tryptophan levels and thereby supporting serotonin production.

A key study by Markus et al. (2000, American Journal of Clinical Nutrition) found that healthy subjects consuming alpha-lactalbumin-enriched diets showed increased plasma tryptophan and an improved tryptophan/large neutral amino acid ratio, which facilitated greater serotonin synthesis. In vulnerable populations, such as individuals with high stress or at risk for depression, some studies report modest improvements in mood or stress resilience after supplementation, likely mediated by enhanced serotonin activity. However, while findings are promising, the evidence is not yet robust; effects are generally modest and more pronounced in those with suboptimal baseline tryptophan or serotonin function.

In summary, there is scientific rationale and moderate evidence for the use of alpha-lactalbumin to support neurotransmitter (especially serotonin) function, though further large, well-controlled trials are needed to confirm clinical benefits and define optimal dosing.

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