Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citicoline (also known as CDP-choline) is primarily supported by scientific evidence for its role in supporting neurotransmitter function. Citicoline serves as a precursor for the synthesis of phosphatidylcholine, an important component of neuronal cell membranes, and provides choline for acetylcholine production—a key neurotransmitter involved in memory and cognitive processes. Several clinical studies have indicated that citicoline supplementation may enhance brain phospholipid synthesis and increase levels of neurotransmitters, including acetylcholine and dopamine, particularly in populations with neurological impairment (e.g., stroke, cognitive decline). For example, randomized controlled trials have demonstrated modest improvements in memory and attention in older adults and patients with cognitive deficits. However, the evidence for healthy adults is less robust, and some studies report only marginal benefits.

Meta-analyses and systematic reviews generally conclude that citicoline is safe and may offer neuroprotective effects, especially in conditions like stroke, vascular dementia, and traumatic brain injury, though results can be variable depending on the clinical context. Its use is not based on traditional or folk medicine but rather on pharmacological research into choline metabolism and neurotransmitter synthesis. While not universally adopted for cognitive enhancement in healthy individuals, the scientific rationale for its support of neurotransmitter systems is moderately strong, especially within clinical settings.

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