Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Deanol, also known as dimethylaminoethanol (DMAE), has been explored for its effects on the central nervous system, particularly regarding its potential to support neurotransmitter function. The rationale stems from its role as a precursor to choline, which is itself a precursor to the neurotransmitter acetylcholine. Acetylcholine is involved in numerous neural processes, including memory, attention, and muscle control. Some early studies from the 1970s and 1980s investigated DMAE supplementation for cognitive enhancement and behavioral disorders such as ADHD and Alzheimer’s disease. Results were mixed and generally not robust; a few studies suggested modest benefits in attention and alertness, while others found no significant effect. The scientific community has since largely moved on, as better-understood and more effective treatments have been developed. Modern reviews and meta-analyses have found insufficient quality evidence to support DMAE’s efficacy in enhancing neurotransmitter function or cognitive performance in healthy individuals or those with neuropsychiatric disorders. DMAE is not approved by regulatory agencies for these uses, and its mechanism of action in humans remains uncertain, as orally ingested DMAE does not reliably increase brain choline or acetylcholine levels. In summary, while there is some scientific rationale and historical research backing its use, the evidence is weak and inconclusive, justifying a low evidence score.

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