Evidence supporting the use of: GABA
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter naturally produced in the brain and plays a crucial role in regulating neuronal excitability throughout the nervous system. Scientific interest in GABA supplementation centers on its potential to influence the "Specific Neurotransmitters" body system, such as modulating anxiety, stress, and sleep by increasing inhibitory signaling in the brain. However, most of the available evidence suggests that orally ingested GABA has poor ability to cross the blood-brain barrier, which limits its direct effect on central nervous system neurotransmission. Some small human studies and animal research report mild anxiolytic or calming effects after GABA supplementation, possibly due to indirect mechanisms or effects on the enteric nervous system, but these findings are inconsistent and often limited by small sample sizes and methodological issues. Overall, while GABA is used in dietary supplements aimed at supporting neurotransmitter balance and relaxation, the current scientific evidence for its efficacy in modulating the central "Specific Neurotransmitters" system is limited, and clinical effects in humans remain modest and not well established.

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