Evidence supporting the use of: GABA (gamma aminobutyric acid)
For the body system: Specific Neurotransmitters

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

GABA (gamma-aminobutyric acid) is an inhibitory neurotransmitter in the central nervous system that plays a crucial role in reducing neuronal excitability and promoting relaxation. As a supplement, GABA is marketed for its potential to support the "Specific Neurotransmitters" body system, particularly in managing stress, anxiety, and sleep. Scientific validation for oral GABA supplementation is limited. Although endogenous GABA is essential for healthy brain function, most studies indicate that orally administered GABA has poor blood-brain barrier permeability, which means that only small amounts, if any, reach the brain to exert a neurological effect. Some small-scale human studies and animal research have suggested that GABA supplementation may have calming effects or improve sleep quality, possibly through indirect pathways such as influencing the enteric nervous system or via the gut-brain axis. However, these findings are preliminary, and larger, well-controlled trials are needed to confirm efficacy and clarify mechanisms. There is relatively little evidence for a direct impact on neurotransmitter function from oral supplementation in humans. Thus, while the rationale for using GABA to support neurotransmitter balance is based on its biochemical role in the brain, robust clinical evidence for the effectiveness of oral GABA supplements is lacking, warranting a moderate but cautious rating.

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Other body systems supported by GABA (gamma aminobutyric acid)

Brain
Nerves
Parasympathetic Nervous System
Specific Neurotransmitters